Article list

NMR Laboratory for Preclinical Research SISCO Tomograph room The in vivo NMR laboratory (SK U 22016, approved by the State Veterinary and Food Administration of the Slovak Republic) is equipped with modern instrumentation and validated protocols for a wide range of MR experiments on animal models. The laboratory is part of the National Centre NMR….

Investigators: Ladislav Valkovič, Pavol Szomolányi Quantifying the concentration of energy metabolites requires accurate measurement of the magnetic field (B1), especially at 7T where the excitation coils face large field inhomogeneities. Measuring the B1 field using standard signal sampling is relatively time-consuming. It takes about 40 minutes to cover the entire heart, which is too long…

Investigator: Radka Klepochová In this work, we focused on obtaining information about two key processes at the same time: the depletion and recovery of intramuscular phosphocreatine (PCr) using ³¹P MRS and the behavior of the creatine CH₂ signal in ¹H MRS, which exhibits similar dynamics. While previous studies required separate ¹H and ³¹P measurements with…

Investigators: Daniel Gogola, Rudolf Tanglmajer, Dušan Mašek For the Ionizing Radiation Department of the Slovak Metrology Institute, a device was developed to automate the measurement of neutron radiation source anisotropy and to measure the response of neutron detectors depending on the angle or angular distribution. Aplicator of the result: Ionizing Radiation Department, Slovak Institute of…

Investigators: Jiří PŘIBIL, Tomáš Dermek As part of the VEGA project, a new prototype of a multi-channel wearable PPG sensor with integrated contact thermo-chips and a pressure sensor based on force-sensitive resistors (FSR) was developed and tested in practice. The sensor is capable of measuring in the weak magnetic field environment of an NMR tomograph….

Investigators: Ladislav Valkovič, Iveta Pajanová Cardiac energy metabolism is still rather dependent on the experience of the operator, both at the acquisition and analysis stages. Mainly because any shift in the acquisition matrix or wrong voxel selection increase inaccuracy, which is one of the reasons why this promising technique is not yet used in clinical…

Investigator: Jiří PŘIBIL In the field of mapping the physiological and mental effects of scanning in MRI tomograph on the examined person, our research in 2024 was focused on refining the method of estimating blood pressure values directly from the PPG signal, without the use of an external blood pressure monitor. Several series of measurement…

Investigator: Ladislav Valkovič, Ústav merania, v. v. i., SAV Our non-invasive methods for energy metabolism assessment using phosphorus MR spectrscopy are ideal for treatment testing in patients, where cardaic or skeletal muscle metabolism is impaired. Hence in collaboration with Boeringer Ingelheim, we have tested the potential mecahnism of effect of their new sodium-glucose co-transporter inhibitor…

Investigators: Jiří PŘIBIL, Anna PŘIBILOVÁ, Ivan Frollo Our research is focused on the analysis of the effects of scanning in NMR tomograph on the cardiovascular system of the examined person in order to find appropriate methods of their detection and quantification, designing measures for their minimization. The impact of stress effects on the human body…

Investigators: Ladislav Valkovič, Ivan Frollo   Alterations in cardiac metabolism are indicative of several diseases. Current data acquisition methods of phosphorus MR spectroscopy (31P-MRS) are even at 7T systems too slow to allow investigations of dynamicchanges or measurements under stress. Therefore, we have developed a new method of spectraspatial encoding, which substitutes typical Cartesian sampling with…