Article list

New method for spectral-spatial encoding using a concentric ring trajectory for rapid cardiac metabolism assessment

Investigators: Ladislav Valkovič, Ivan Frollo   Alterations in cardiac metabolism are indicative of several diseases. Current data acquisition methods of phosphorus MR spectroscopy (31P-MRS) are even at 7T systems too slow to allow investigations of dynamicchanges or measurements under stress. Therefore, we have developed a new method of spectraspatial encoding, which substitutes typical Cartesian sampling with…

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Biomedical research on the effects of the electromagnetic field at the cellular and subcellular level

Investigators: Michal Teplan, Hoang Vu Viet In the area of ​​the effect of pulsed electric fields (PEF) on sub-cellular structures, we investigated the manipulation of microtubules (MT) using PEF. In cooperation with ÚFE AVČR, we created new statistical measures for measuring MT movement for images from the “single molecule TIRF” microscope, which we called “microtubule…

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Biological autoluminescence as a non-invasive tool for monitoring chemical and physical oxidation modulation in yeast cell cultures

Investigators: Michal Teplan, Martin Bereta Oxidative metabolism is a process that occurs in organisms during their physiological and pathophysiological conditions. Monitoring biological oxidation processes caused by chemical or physical stimuli is currently extremely important due to the environmental burden of various physicochemical factors. Existing techniques usually require the addition of chemical markers or illumination, which,…

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Method for rapid and complete quantification of myocardial ATP flux using saturation transfer with dual-band quasi-adiabatic pulse

Investigators: Ladislav Valkovič, Ivan Frollo Adenosine triphosphate (ATP) is an organic compound that provides energy to drive all processes in living cells, such as: muscle contraction or nerve impulse propagation. Phosphorus saturation-transfer experiments can be used to quantify metabolic fluxes of ATP noninvasively. Typically, only the forward ATP synthesis flux through the creatine kinase reaction…

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Application of gadolinium-based contrast agents in magnetic resonance imaging methods, prediction for patients with untreated patellar cartilage lesions

Investigator: Szomolányi, P. Many factors influence the increase in signal intensity provided by magnetic resonance imaging (MRI) contrast media. Purpose: To assess the impact of different gadolinium concentrations and dilutions of three macrocyclic gadolinium-based contrast agents. The test tubes were positioned in a rack in a silicon oil bath to maintain the temperature at 370C…

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