Contacts
Intranet
SK
Martin Škrátek
National projects
| SQUIDiron – Determination of Iron in blood and tissues of laboratory animals using SQUID magnetometer. | |
| Stanovenie množstva železa v krvi a tkanivách laboratórnych zvierat pomocou SQUID magnetometra | |
| Program: | Plán obnovy EÚ |
| Duration: | 1.9.2024 – 31.8.2026 |
| Project leader: | Mgr. Škrátek Martin, PhD. |
| Annotation: | Iron is an essential chemical element that is part of many metabolic processes. However, the amount of iron in the body must be balanced, as its excess or deficiency can lead to serious health conditions. Iron is found in the body in ferritin, hemoglobin or transferrin proteins. Deoxyhemoglobin, methemoglobin, and myoglobin are known to exhibit paramagnetism, which originates from the Fe2+ Fe3+ ions embedded in their molecules. Ferritin, as an iron storage protein, contains Fe atoms mineralized in the form of oxyhydroxide nanoparticles, whose behavior is superparamagnetic. SQUID magnetometry offers the possibility of detecting and quantifying different forms of iron with high sensitivity and could be more useful than other established methods (colorimetric, spectrophotometric, histochemical or atomic absorption spectrometry) in determining the amount of iron in small samples. |
| SQUID magnetometry of nano- and microparticles, nanocolloids and nanostructures in new applications in the field of biomedicine and materials research associated with the development of new measurement methods and procedures | |
| SQUID magnetometria nano-a mikročastíc, nanokoloidov a nanoštruktúr v nových aplikáciach v oblasti biomedicíny a materiálového výskumu spojených s rozvojom nových meracích metód a postupov | |
| Program: | VEGA |
| Duration: | 1.1.2021 – 31.12.2024 |
| Project leader: | Ing. Maňka Ján, CSc. |
| Annotation: | The theme of the project is the development of magnetic measurement methods and methodologies forbiomedicine and materials research. Its aim is to contribute to a better understanding of the following: impact of stress on iron metabolism at the systemic and cellular levels; magnetic properties of metal proteins such as transferrin, haemoglobin, and ferritin; thermal and photoluminescent properties of aluminous glasses doped with rare earth elements and transition elements; magnetic properties of high-entropy alloys, and colloids of the high-entropy alloys nanoparticles in ionic liquids – actors with a high application impact on the development of new measurement methods, instrumentation and a new generation of ecological industrial applications. The interdisciplinary character of the project is given by the studied samples and research themes. |
| Role of nuclear factor NRF2-mediated signalling in iron metabolism regulation during stress | |
| Úloha signalizácie sprostredkovanej jadrovým faktorom NRF2 v regulácii metabolizmu železa počas stresu | |
| Program: | VEGA |
| Duration: | 1.1.2021 – 31.12.2024 |
| Project leader: | Mgr. Škrátek Martin, PhD. |
| Annotation: | Stress is considered to be an etiological factor associated with the development of various chronicnon-communicable diseases. Stress may also alter iron metabolism. Nuclear factor erythroid 2-related factor 2(NRF2)-regulates several genes involved in iron metabolism. Despite the accelerating information on the roles of NRF2, less is known about the NRF2 signalling in iron metabolism in conditions of stress. Thus, the aim of this project is to investigate the role of NRF2 signalling in iron metabolism in conditions of acute and chronic stress in rats with genetic predisposition to hypertension. In addition, the effects of pharmacological activation of NRF2 signalling and the distinct roles of inducible and endothelial nitric oxide synthases in iron metabolism in stress conditions will be investigated. Project will bring the original results about NO and NRF2-mediated regulation of iron metabolism and the involvement of altered iron metabolism in the development of cardiovascular and metabolic disorders. |