Analysis of Significance of Multi-Lead ECG Electrodes and Their Influence on Accuracy of Inverse Solution

Investigators: Beáta Ondrušová, Jana Švehlíková, Ján Zelinka, Milan Tyšler, Peter Tiňo

 

In the study, we proposed a methodology for determining the significance of signals from individual electrodes of multichannel ECG measurement for solving the inverse problem to locate the source of the ventricular extrasystole. This method is based on the singular decomposition of the transfer matrix, which describes the relationship between the cardiac generator and the potentials measured on the chest. The results showed that the electrodes whose signals most significantly affect the inverse solution are located in close proximity to the site of ventricular activity and their position is different depending on the position of the source [1]. The results further showed that by using a subset that contains only the signals that most significantly affect the inverse solution, we can in some cases obtain more accurate results of the inverse localization [2]. With these conclusions, the study brings new knowledge about the location of important leads and their impact on the inverse solution, which in the future may contribute to a more accurate localization of the site of ectopic ventricular activity.

 

Related projects: VEGA 2/0125/19 “Measurement and modeling of the electric field of the heart for non-invasive identification and interpretation of structural changes in the ventricular myocardium leading to ventricular arrhythmias.” APVV-19-0531 “Personalized optimization of resynchronization treatment of heart failure based on multi-lead ECG measurement”

 

Publications:

• ONDRUŠOVÁ, Beáta – ŠVEHLÍKOVÁ, Jana – TYŠLER, Milan – TIŇO, P. Significance of multi-lead ECG electrodes derived from patient-specific transfer matrix. In MEASUREMENT 2021 : Proceedings of the 13th International Conference on Measurement. – Bratislava : Institute of Measurement Science, SAS, 2021, 2021, p. 80-83. ISBN 978-80-972629-4-5. Typ: ADNB
• ONDRUŠOVÁ, Beáta – ŠVEHLÍKOVÁ, Jana – ZELINKA  Ján  –TYŠLER, Milan – TIŇO, P. Model-Based Relevance of Measuring Electrodes for the Inverse Solution with a Single Dipole. In Computing in Cardiology, 2021. Typ: ADMB (v tlači)

Fig.: Positions of 20% of electrodes, whose signals most significantly influence the solution of the inverse problem of electrocardiography to locate the source of ectopic ventricular activity. Electrode positions for four different sites of ectopic ventricular activation are shown (black cross), the significance of the positions differs in color from the most important (max v).