Two-steps algorithm for computing the inverse solution of electrocardiography

Investigators: Beáta Ondrušová, Peter Tiňo, Jana Švehlíková

This study addresses the non-invasive localization of cardiac abnormalities, specifically premature ventricular contractions (PVCs), through a newly proposed two-stage inversion solution for a dipole cardiac source. One of the inputs for solving the inversion problem is the surface potentials measured using a large number (128) of electrodes placed on the patient’s chest (called surface mapping). In this work, we evaluated the significance of each electrode using our proposed “greedy” algorithm and in a second step we solved the inverse problem using only the significant electrodes. The results revealed inter-patient variability in the importance of surface electrodes. By comparing localization error values, we demonstrated that accurate localization of PVCs can be achieved using a carefully selected subset (e.g., 64) of electrodes. These results highlight the potential of using a reduced number of electrodes to solve the inversion problem, which would make it possible to implement a more convenient and patient-friendly surface mapping method. The results are part of a dissertation that will be submitted by the end of 2023.

Related project: VEGA 2/0109/22

Figure 1: Schematic of the two-step algorithm for computing the inverse problem

Publications 2023:

• ONDRUŠOVÁ, Beáta** – TIŇO, P. – ŠVEHLÍKOVÁ, Jana. A two-step inverse solution for a single dipole cardiac source. In Frontiers in Physiology, 2023, vol. 14, art. no. 1264690. (2022: 4 – IF, Q2 – JCR, 1.028 – SJR, Q1 – SJR). ISSN 1664-042X. Dostupné na: https://doi.org/10.3389/fphys.2023.1264690 (VEGA č. 2/0109/22 : Use of multi-lead ECG measurement and modeling of the electric field of the heart in non-invasive diagnostics and therapy of ventricular arrhythmias and heart failure) Typ: ADCA
• ONDRUŠOVÁ, Beáta** – TIŇO, P. – ŠVEHLÍKOVÁ, Jana. The significance of the torso electrodes for selected cardiac regions. In Proceedings of the 14th International Conference on Measurement. 1. vyd. – Bratislava : Institute of Measurement Science, SAS, 2023, p. 6-9. ISBN 978-80-972629-7-6. Dostupné na: https://doi.org/10.23919/MEASUREMENT59122.2023.10164569 (VEGA č. 2/0109/22 : Use of multi-lead ECG measurement and modeling of the electric field of the heart in non-invasive diagnostics and therapy of ventricular arrhythmias and heart failure. APVV-19-0531 : Personalized optimisation of cardiac resynchronization therapy in heart failure based on multiple lead ECG measurement) Typ: ADNB
• ONDRUŠOVÁ, Beáta** – TIŇO, P. – ŠVEHLÍKOVÁ, Jana. Inverse Solution Accuracy Using 12-Lead ECG vs. 9 Significant Electrodes Derived by Greedy Algorithm. In Computing in Cardiology, 2023, vol. 50, p. non. Typ: ADMB, in print.