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Intranet
SK
National projects
| MRCartilage – Automatic data evaluation tool from the longitudinal quantitative MRI studies of articular cartilage | |
| Automatický softvérový nástroj na výhodnocovanie kvantitatívnych MRI štúdií artikulárných chrupaviek v čase | |
| Program: | APVV |
| Duration: | 1.7.2022 – 30.6.2026 |
| Project leader: | Ing. Dr. Szomolányi Pavol, (PhD.) |
| Annotation: | The aim of the project is to design a comprehensive tool for automatic evaluation of human articular cartilage data from quantitative MRI. Data obtained from the Osteoarthritis Initiative database, and measured at Institute of Measurement Science and Medical University of Vienna will be segmented using an automated segmentation tool based on convolutional neural networks. The annotated data will then be registered on quantitative MRI data that will be available from the database (T2 and T1rho mapping, gagCEST, sodium MR) using automated or semiautomated tools developed within this project. The data obtained will be evaluated at multiple time points according to MR measurements that will be available. In addition to quantitative MR data, this will include volumetric data, cartilage thickness, and texture analysis of quantitative maps. Patient evaluation will be based on risk factor groups (transverse ligament rupture, meniscus rupture and menisectomy). The expected number of patients is approximately 4000 divided into individual groups in the ratio 40/30/30. The output of the project will be a compiled version of an automatic cartilage evaluation tool that will be available in a public source (such as website of Institute of Measurement). |
| ITAGES – Identification of stress-induced alterations in expression of NRF2 target genes in rat models of prehypertension: the effect of comorbid hypertriglyceridemia and dimethyl fumarate treatment | |
| Identifikácia stresom vyvolaných zmien v expresii cieľových génov NRF2 v potkaních modeloch prehypertenzie: vplyv komorbidnej hypertriglyceridémie a liečby dimetylfumarátom | |
| Program: | APVV |
| Duration: | 1.7.2023 – 30.6.2027 |
| Project leader: | Ing. Maňka Ján, CSc. |
| Annotation: | The nuclear transcription factor erythroid 2-related factor 2 (NRF2) is a key molecular link between several non-communicable diseases, as it regulates the expression of approximately 250 target genes, including those involvedin maintenance of redox balance, the development of metabolic disorders, cardiovascular and liver diseases, aswell as in immune responses. Borderline elevated blood pressure (prehypertension) is a common cardiovasculardisorder in humans, and elevated blood pressure has been found to be positively correlated with triglyceride levels.In addition, chronic stress is an etiological factor in the development of non-communicable diseases, includingelevated blood pressure and hypertriglyceridemia (HTG). In experimental studies, borderline hypertensive rats(BHR) and hypertriglyceridemic rats (HTGR) are suitable models of prehypertension without and with comorbidhypertriglyceridemia. These models are relevant for investigating the effects of stress as well as for investigatingthe role of changes in expression of NRF2 target genes in the development of hypertension associated withmetabolic diseases. To understand better the role of NFR2 as well as the impact of chronic social stress on thementioned diseased states, the aims of this project are: 1) to identify differences in expression of NRF2 targetgenes in two experimental models of prehypertension – without (in BHR) and with (in HTGR) comorbid HTG – incontrol conditions and during chronic social stress, 2) to determine if NRF2 activator dimethyl fumarate can reducestress-induced pathologies in prehypertensive rats, especially in those with comorbid HTG, and 3) to specify a setof suitable whole blood RNA biomarkers for evaluation of changes in NRF2 target genes in prehypertension andHTG and those genes altered by chronic social stress. |
| SQUIDiron – Determination of Iron in blood and tissues of laboratory animals using SQUID magnetometer. | |
| Stanovenie množstva železa v krvi a tkanivách laboratórnych zvierat pomocou SQUID magnetometra | |
| Program: | Plán obnovy EÚ |
| Duration: | 1.9.2024 – 31.8.2026 |
| Project leader: | Mgr. Škrátek Martin, PhD. |
| Annotation: | Iron is an essential chemical element that is part of many metabolic processes. However, the amount of iron in the body must be balanced, as its excess or deficiency can lead to serious health conditions. Iron is found in the body in ferritin, hemoglobin or transferrin proteins. Deoxyhemoglobin, methemoglobin, and myoglobin are known to exhibit paramagnetism, which originates from the Fe2+ Fe3+ ions embedded in their molecules. Ferritin, as an iron storage protein, contains Fe atoms mineralized in the form of oxyhydroxide nanoparticles, whose behavior is superparamagnetic. SQUID magnetometry offers the possibility of detecting and quantifying different forms of iron with high sensitivity and could be more useful than other established methods (colorimetric, spectrophotometric, histochemical or atomic absorption spectrometry) in determining the amount of iron in small samples. |