Methods of extremely sensitive magnetometry in biomedicine and materials researc

Investigators: M. Škrátek, J. Maňka

 

Measurement of magnetic quantities with high sensitivity finds application in various areas of scientific research. In our research, in cooperation with other scientific institutions, we focused on the use of nanoparticles in biomedicine and on two issues in the field of materials research. Ultra-small superparamagnetic iron oxide nanoparticles in appropriate biocompatible packaging are often used in biomedicine. The study was focused on the investigation of the deformability of red blood cells of laboratory animals after the application of said nanoparticles. Our contribution was to determine the content of iron in the blood coming from nanoparticles in their original form. In another study, we participated in the research of a hybrid inorganic-organic compound. These complex structures, based on the composition of inorganic and organic components at the molecular level, provide the potential for the design of new functional materials. The magnetic properties of the compound [Cu (en) 2 (VO3) 2] • 3H2O were investigated. Measurements of temperature magnetization and hysteresis dependence showed that the compound is paramagnetic (1.79 µB) and shows no significant magnetic interactions. In the last study, we investigated the effects of magnetized halloysite (MHNT) on the structure, morphology, chemical composition and magnetic and mechanical properties of electrospun nanofibers based on mixtures of polycaprolactone (PCL) and gelatin (gel). It was found that the incorporation of 12 wt. % MHNT to PCL / gel nanofibers resulted in the formation of a magnetic biocompatible material with a saturation magnetization of 0.67 Am2 / kg and a coercivity of 1194 A / m.

 

Related projects: APVV-16-0263, VEGA 2/0157/21, VEGA 1/0141/21, VEGA 2/0164/17.

 

The results were achieved in cooperation with the Center for Experimental Medicine of the Slovak Academy of Sciences, the Institute of Inorganic Chemistry of the Slovak Academy of Sciences and other domestic and foreign university workplaces.

 

Publications:

 

  • RADOŠINSKÁ, J. – JASENOVEC, T. – RADOŠINSKÁ, D. – BALIŠ, P. – PÚZSEROVÁ, A. – ŠKRÁTEK, Martin – MAŇKA, Ján – BERNÁTOVÁ, I. Ultra-small superparamagnetic iron-oxide nanoparticles exert different effects on erythrocytes in normotensive and hypertensive rats. In Biomedicines, 2021, vol. 9, no. 4, art. no. 377. ISSN 2227-9059. (6.081 – IF2020) Q1, (ADCA).
  • KHUNOVÁ, V. – PAVLIŇÁK, D. – ŠAFAŘÍK, I. – ŠKRÁTEK, Martin – ONDREÁŠ, F. Multifunctional electrospun nanofibers based on biopolymer blends and magnetic tubular halloysite for medical applications. In Polymers, 2021, vol. 13, no. 22, p. 3870. ISSN 2073-4360. (4.329 – IF2020) Q1, (ADCA).
  • STEHLÍKOVÁ, G. – GYEPES, R. – BYSTRICKÝ, R. – ŠKRÁTEK, Martin – PŘEMYSL, V. – TATIERSKY, J. Thermal properties of the hybrid compound [Cu(en)2(VO3)2]•3H2O — phase analysis upon heating and cooling. Crystal structure characterization of its two polymorphic modifications. In Journal of Molecular Structure, 2021, vol. 1230, art. no. 129930. ISSN 0022-2860. (3.196 – IF2020) Q2, (ADCA).