Exploration of the electroporation process through dynamical methods of signal processing

Seminar of Department of Theoretical Methods

Institute of Measurement Science, Slovak Academy of Sciences

 

 

Exploration of the electroporation process

through dynamical methods of signal processing

 

 

On Thursday, July 25th 2019, 11 am

 

Djamel Eddine Chafai¹, Michal Teplan², Damijan Miklavcic³

¹Institute of photonics and electronics, Czech Academy of Sciences, Czech Republic

²Institute of Measurement Science, Slovak Academy of Sciences

³University of Ljubljana, Faculty of Electrical Engineering, Laboratory of Biocybernetics, Ljubljana, Slovenia

 

 

Despite the success and the intensive use of electroporation in medicine and biotechnology, e.g. for cancer treatment, the understanding of the phenomenon of induced molecular paths by pulsed electric fields is still incomplete. In addition to these induced electro-molecular paths, pulsed electric fields induce electrochemical processes at the same phenomenological time scale. The common denominator of these different microscopic processes is their highly nonlinear dynamics for which different signal analysis approaches can be applied in order to distinguish different electroporation subprocesses. We will present results from signal analysis of the electroporation current time series. The main advantage of this approach in comparison to the conventional methods, e.g. molecular dynamics, biochemical techniques, is that this analysis explores the electroporation process from its on-time recordings.